PHYSICOCHEMICAL PROPERTIES THAT CONTROL PROTEIN AGGREGATION ALSO DETERMINE WHETHER A PROTEIN IS RETAINED OR RELEASED FROM NECROTIC CELLS

Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells

Amyloidogenic protein aggregation impairs cell function and is a hallmark of many chronic degenerative disorders.Protein aggregation is also a major event during acute injury; however, unlike amyloidogenesis, the process of injury-induced protein aggregation remains largely undefined.To provide this insight, we profiled the insoluble proteome of se

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